5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Name:5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1382782-95-7
Molecular Formula:C₁₈H₁₆FN₅O₃
Molecular Weight:369.355
Hs Code.:

Synonyms:5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Technology Process of 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 5 articles about 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1382782-07-1
2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

: 37554-70-4
2-chloro-5-fluoro-4-methoxy-pyrimidine

: 1382782-95-7
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; at 120 ℃; for 16h; Sealed tube; Inert atmosphere;

Reference yield:

: 856256-81-0
2,4-dioxo-5-phenoxypentanoic acid ethyl ester

: 1382782-95-7
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.2: 72 h / 20 °C / Saturated solution

4.1: caesium carbonate; XPhos / palladium diacetate / 16 h / 120 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; potassium carbonate; caesium carbonate; hydrazine hydrate; XPhos; palladium diacetate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 856256-82-1
3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester

: 1382782-95-7
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.2: 72 h / 20 °C / Saturated solution

3.1: caesium carbonate; XPhos / palladium diacetate / 16 h / 120 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; potassium carbonate; caesium carbonate; XPhos; palladium diacetate; In 1,4-dioxane; N,N-dimethyl-formamide;