7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

Chemical Name:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497853-49-3
Molecular Formula:C₄₀H₅₀N₄O₃S
Molecular Weight:666.928
Hs Code.:

Synonyms:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 6 articles about 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(chloromethyl)-1-propyl-1H-imidazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 313736-34-4
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 497853-49-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 1h;

S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

4-(chloromethyl)-1-propyl-1H-imidazole hydrochloride; With sodium hydroxide; more than 3 stages;

Reference yield:

: 4-(chloromethyl)-1-propyl-1H-imidazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497853-49-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; 7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

4-(chloromethyl)-1-propyl-1H-imidazole hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 343269-72-7
(1-propyl-1H-imidazol-4-yl)methanol

: 497853-49-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-4-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.10.021