N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

Base Information

Chemical Name:N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine
CAS No.:153737-58-7
Molecular Formula:C₃₁H₂₈N₅O₂P
Molecular Weight:533.569
Hs Code.:

Synonyms:N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

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Chemical Property of N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

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Technology Process of N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

There total 7 articles about N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 603-35-0
triphenylphosphine

: 153830-48-9
(-)-β-(4'β-hydroxy-2'α,3'α-O-isopropylidenedioxycyclopent-1'-yl)-9-H-adenine

: 153737-58-7
N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

Guidance literature:: With 1H-imidazole; iodine; In toluene; at 120 ℃; for 18h;
DOI:10.1016/S0040-4039(00)61691-X

Reference yield:

: 60410-16-4
(1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate

: 153737-58-7
N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / NaH, Pd(PPh₃)4 / dimethylformamide / 18 h / 60 °C

2: 85 percent / pyridine / 3 h / 65 °C

3: 90 percent / osmium tetroxide, trimethylamine N-oxide / dimethylformamide; acetone; H₂O / 15 h / Ambient temperature

4: 95 percent / p-TsOH*H₂O / 60 h / Ambient temperature

5: 75 percent / aq. NaOH / methanol / 12 h / Ambient temperature

6: 70 percent / imidazole, iodine / toluene / 12 h / 120 °C

With 1H-imidazole; sodium hydroxide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylamine-N-oxide; iodine; sodium hydride; toluene-4-sulfonic acid; In pyridine; methanol; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1080/07328319808004308

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 153737-58-7
N6-triphenylphosphinimino-(2'α,3'α-O-isopropylidendioxy-4'-cyclopenten-1'β-yl)-9-H-adenine

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / NaH, Pd(PPh₃)4 / dimethylformamide / 18 h / 60 °C

2: 85 percent / pyridine / 3 h / 65 °C

3: 90 percent / osmium tetroxide, trimethylamine N-oxide / dimethylformamide; acetone; H₂O / 15 h / Ambient temperature

4: 95 percent / p-TsOH*H₂O / 60 h / Ambient temperature

5: 75 percent / aq. NaOH / methanol / 12 h / Ambient temperature

6: 70 percent / imidazole, iodine / toluene / 12 h / 120 °C

With 1H-imidazole; sodium hydroxide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylamine-N-oxide; iodine; sodium hydride; toluene-4-sulfonic acid; In pyridine; methanol; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1080/07328319808004308