4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide

Base Information

• Chemical Name: 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide
• CAS No.: 1431470-13-1
• Molecular Formula: C₁₈H₁₉N₅O₃
• Molecular Weight: 353.381
• Mol file: 1431470-13-1.mol

Synonyms:4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide

Chemical Property of 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide

There total 5 articles about 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-bromo-pyridine-2-carboxylic acid benzyl(tetrahydropyran-2-yloxy)amide (1431470-12-0) → 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide (1431470-13-1)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 80 ℃; for 48h;

Reference yield:

4-bromo-2-picolinic acid (30766-03-1) → 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide (1431470-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

1.2: 18 h / 20 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran / 48 h / 65 °C

3.1: sodium azide / water; N,N-dimethyl-formamide / 24 h / 80 °C

With sodium azide; oxalyl dichloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

4-bromopyridine-2-carboxylic acid benzylhydroxyamide (1431470-11-9) → 4-azido-pyridine-2-carboxylic acid benzyl-(tetrahydro-pyran-2-yloxy)amide (1431470-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 48 h / 65 °C

2: sodium azide / water; N,N-dimethyl-formamide / 24 h / 80 °C

With sodium azide; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-pyridine-2-carboxylic acid benzyl(tetrahydropyran-2-yloxy)amide

4-bromo-2-picolinic acid

4-bromopyridine-2-carboxylic acid benzylhydroxyamide

4-bromopyridine-2-carbonyl chloride

Downstream raw materials:

4-aminopyridine-2-carboxylic acid benzyl(tetrahydropyran-2-yloxy)amide