N,N-dimethyl-α-phenylmalonamic acid

Base Information

• Chemical Name: N,N-dimethyl-α-phenylmalonamic acid
• CAS No.: 259248-79-8
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 259248-79-8.mol

Synonyms:N,N-dimethyl-α-phenylmalonamic acid

Chemical Property of N,N-dimethyl-α-phenylmalonamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-α-phenylmalonamic acid

There total 3 articles about N,N-dimethyl-α-phenylmalonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Phenylmalonsaeure-aethylester-dimethylamid (26739-86-6) → N,N-dimethyl-α-phenylmalonamic acid (259248-79-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Ambient temperature;

Reference yield:

2-phenylmalonic acid monoethyl ester (17097-90-4) → N,N-dimethyl-α-phenylmalonamic acid (259248-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 18.6 g / thionyl chloride / CH₂Cl₂ / 20 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 0 °C

3: 87 percent / sodium hydroxide / aq. ethanol / 2 h / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; In ethanol; dichloromethane;

Reference yield:

2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester (113932-23-3,54635-33-5) → N,N-dimethyl-α-phenylmalonamic acid (259248-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0 °C

2: 87 percent / sodium hydroxide / aq. ethanol / 2 h / Ambient temperature

With pyridine; sodium hydroxide; In ethanol; dichloromethane;

upstream raw materials:

Phenylmalonsaeure-aethylester-dimethylamid

2-phenylmalonic acid monoethyl ester

2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester

Downstream raw materials:

N-[2-(3,4-dimethoxyphenyl)ethyl]-N-(4-methoxyphenyl)-N',N'-dimethyl-2-phenylmalonamide

Refernces