2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

Base Information

Chemical Name:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone
CAS No.:1380428-25-0
Molecular Formula:C₂₆H₁₇ClF₆N₂O₃
Molecular Weight:554.876
Hs Code.:

Synonyms:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

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Chemical Property of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

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Technology Process of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

There total 4 articles about 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.23%

: 1380429-42-4
ethyl 2-formyl-3-(2,4,6-trifluorophenyl)propanoate

: 1380429-43-5
2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate

: 1380428-25-0
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

Guidance literature:: With caesium carbonate; In toluene; for 12h; Reflux;

Reference yield:

: 58551-83-0
2,4,6-trifluorobenzaldehyde

: 1380428-25-0
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 0.75 h / 0 - 20 °C

2.1: formic acid; triethylamine / palladium 10% on activated carbon / water; ethyl acetate / 1 h / 90 °C / Inert atmosphere; Reflux

3.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

4.1: caesium carbonate / toluene / 12 h / Reflux

With formic acid; potassium tert-butylate; sodium hydride; caesium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1257121-73-5
(E)-ethyl 3-(2,4,6-trifluorophenyl)acrylate

: 1380428-25-0
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-[(2,4,6-trifluorophenyl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid; triethylamine / palladium 10% on activated carbon / water; ethyl acetate / 1 h / 90 °C / Inert atmosphere; Reflux

2: sodium hydride / 1,2-dimethoxyethane / 20 °C

3: caesium carbonate / toluene / 12 h / Reflux

With formic acid; sodium hydride; caesium carbonate; triethylamine; palladium 10% on activated carbon; In 1,2-dimethoxyethane; water; ethyl acetate; toluene;