14-Thioglycolamido-7,8-dihydromorphinone

Base Information

Chemical Name:14-Thioglycolamido-7,8-dihydromorphinone
CAS No.:139292-26-5
Molecular Formula:C₁₉H₂₂N₂O₄S
Molecular Weight:374.461
Hs Code.:
DSSTox Substance ID:DTXSID70930426
Mol file:139292-26-5.mol

Synonyms:14-beta-(thioglycolamido)-7,8-dihydromorphinone;14-thioglycolamido-7,8-dihydromorphinone;TAMO

Suppliers and Price of 14-Thioglycolamido-7,8-dihydromorphinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 14-Thioglycolamido-7,8-dihydromorphinone

Chemical Property:

Vapor Pressure:4.36E-17mmHg at 25°C
Boiling Point:642.1°Cat760mmHg
Flash Point:342.2°C
PSA：121.16000
Density:1.47g/cm³
LogP:1.57710
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:374.13002836
Heavy Atom Count:26
Complexity:660

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)NC(=O)CS
Isomeric SMILES:CN1CCC23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)NC(=O)CS

Technology Process of 14-Thioglycolamido-7,8-dihydromorphinone

There total 3 articles about 14-Thioglycolamido-7,8-dihydromorphinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14β-amino-7,8-dihydromorphinone dihydrochloride

: 139292-26-5
14β-(thioglycolamido)-7,8-dihydromorphinone

Guidance literature:: Multi-step reaction with 3 steps

1: 70.4 percent / Et₃N / CH₂Cl₂ / 4 h / 25 °C

2: 46 percent / aq. K₂CO₃ / methanol / 0.5 h / Ambient temperature

3: 3 h / Ambient temperature; pH 7.4

With potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00037a008

Reference yield:

: 155270-55-6
C₂₅H₂₈N₂O₇S₂

: 139292-26-5
14β-(thioglycolamido)-7,8-dihydromorphinone

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / aq. K₂CO₃ / methanol / 0.5 h / Ambient temperature

2: 3 h / Ambient temperature; pH 7.4

With potassium carbonate; In methanol;
DOI:10.1021/jm00037a008