Technology Process of 1-benzenesulfonyl-4-methoxy-6,7,8,9-tetrahydro-1H-naphtho[1,2-c]furan-3-one
There total 6 articles about 1-benzenesulfonyl-4-methoxy-6,7,8,9-tetrahydro-1H-naphtho[1,2-c]furan-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo301712b
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetone / 3 h / Reflux
2.1: potassium hydroxide; water / 0.5 h / Reflux
3.1: oxalyl dichloride / benzene; N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere
4.1: tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere
5.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / 0.75 h / -78 - 20 °C / Inert atmosphere
5.2: 12 h / 20 °C
6.1: acetic acid; hydrogenchloride; water / 10 h / Reflux
7.1: toluene-4-sulfonic acid / benzene / 10 h / Dean-Stark; Reflux
8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
hydrogenchloride; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; water; tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo301712b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere
2.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / 0.75 h / -78 - 20 °C / Inert atmosphere
2.2: 12 h / 20 °C
3.1: acetic acid; hydrogenchloride; water / 10 h / Reflux
4.1: toluene-4-sulfonic acid / benzene / 10 h / Dean-Stark; Reflux
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; water; tert.-butyl lithium; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo301712b
![4-methoxy-1-phenylsulfanyl-6,7,8,9-tetrahydro-1H-naphtho[1,2-c]furan-3-one](/Databaselist/images/loading.webp)
