diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate

Base Information

• Chemical Name: diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate
• CAS No.: 1606169-23-6
• Molecular Formula: C₂₀H₂₁N₄O₅P
• Molecular Weight: 428.384
• Mol file: 1606169-23-6.mol

Synonyms:diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate

Chemical Property of diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate

There total 3 articles about diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-chloro-6-(3-nitrophenyl)-pyrimidine (915069-51-1) + diethyl (4-aminophenyl)phosphonate (42822-57-1) → diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate (1606169-23-6)

Guidance literature:

diethyl (4-aminophenyl)phosphonate; With hydrogenchloride; In 1,4-dioxane; ethanol; water;

4-chloro-6-(3-nitrophenyl)-pyrimidine; In 1,4-dioxane; ethanol; water; isopropyl alcohol; Reflux;

DOI:10.1021/jm401742r

Reference yield:

para-nitro-phenylphosphonate diethylique (1754-42-3) → diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate (1606169-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 4 h / Reflux

2.1: hydrogenchloride / ethanol; water; 1,4-dioxane

2.2: Reflux

With hydrogenchloride; tin(ll) chloride; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm401742r

Reference yield:

para-nitrophenyl bromide (586-78-7) → diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate (1606169-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 20 h / Inert atmosphere; Reflux

2.1: tin(ll) chloride / ethanol / 4 h / Reflux

3.1: hydrogenchloride / ethanol; water; 1,4-dioxane

3.2: Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; tin(ll) chloride; In 1,4-dioxane; ethanol; water; toluene;

DOI:10.1021/jm401742r

upstream raw materials:

4-chloro-6-(3-nitrophenyl)-pyrimidine

diethyl (4-aminophenyl)phosphonate

para-nitro-phenylphosphonate diethylique

para-nitrophenyl bromide

Downstream raw materials:

diethyl (4-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}phenyl)phosphonate

(4-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}phenyl)phosphonic acid