methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate

Base Information

• Chemical Name: methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate
• CAS No.: 863504-80-7
• Molecular Formula: C₁₄H₁₀F₂O₄
• Molecular Weight: 280.228
• Mol file: 863504-80-7.mol

Synonyms:methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate

Chemical Property of methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate

There total 3 articles about methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-(3,5-difluorophenoxy)-5-(tosyloxy)benzoate (863504-81-8) → methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate (863504-80-7)

Guidance literature:

With potassium hydroxide; In methanol; at 50 ℃; for 1h;

DOI:10.1016/j.ejmech.2017.07.051

Reference yield:

methyl 3-hydroxy-5-(tosyloxy)benzoate (178679-02-2) → methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate (863504-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; triethylamine / dichloromethane / 36 h / 20 °C / Molecular sieve

2: potassium hydroxide / methanol / 1 h / 50 °C

With copper diacetate; triethylamine; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2017.07.051

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → methyl 3-(3,5-difluorophenoxy)-5-hydroxybenzoate (863504-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; diethyl ether / 48 h / 20 °C

2: copper diacetate; triethylamine / dichloromethane / 36 h / 20 °C / Molecular sieve

3: potassium hydroxide / methanol / 1 h / 50 °C

With copper diacetate; sodium hydrogencarbonate; triethylamine; potassium hydroxide; In methanol; diethyl ether; dichloromethane; water;

DOI:10.1016/j.ejmech.2017.07.051

upstream raw materials:

methyl 3-(3,5-difluorophenoxy)-5-(tosyloxy)benzoate

methyl 3-hydroxy-5-(tosyloxy)benzoate

1-carbomethoxy-3,5-dihydroxybenzene

Downstream raw materials:

methyl (S)-3-(3,5-difluorophenoxy)-5-((1-methoxypropan-2-yl)oxy)benzoate

Refernces

• 1、 -. "BENZAMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATING AGENTS". Page/Page column 94-95. . Retrieved 2008/06/13.