tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate
CAS No.:1446792-98-8
Molecular Formula:C₂₅H₃₇N₇O₄
Molecular Weight:499.613
Hs Code.:

Synonyms:tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

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Chemical Property of tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

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Technology Process of tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

There total 5 articles about tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1446792-96-6
6-chloro-4-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazine-3-carboxamide

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1446792-98-8
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 60h;

Reference yield: 32.0%

: 1446791-41-8
6-chloro-4-(6-isopropylpyridin-2-ylamino)pyridazine-3-carboxamide

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1446792-98-8
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 60h;
DOI:10.1021/jm401982j

Reference yield:

: 679406-03-2
4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester

: 1446792-98-8
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 21 h / 140 °C

2: ammonia / methanol / 42 h / 50 °C

3: 1-methyl-pyrrolidin-2-one / 60 h / 140 °C

With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;
DOI:10.1021/jm401982j