6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

Base Information

Chemical Name:6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one
CAS No.:1400633-81-9
Molecular Formula:C₁₉H₁₈N₄O₂
Molecular Weight:334.378
Hs Code.:

Synonyms:6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

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Chemical Property of 6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

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Technology Process of 6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

There total 3 articles about 6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1400633-56-8
6-(5-methylpyridin-2-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

: 1400633-81-9
6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: With hydrogenchloride; hydrogen; Raney nickel; In methanol; at 20 - 30 ℃;

Reference yield:

: 1400633-90-0
7-chloro-5-methylsulfanyl-2-phenoxymethylimidazo[1,2-c]pyrimidine

: 1400633-81-9
6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / water; tetrahydrofuran / 4 h / 50 °C

2: hydrogen; 10 wt% Pd(OH)2 on carbon; triethylamine / ethyl acetate; methanol / 16 h / 50 °C / 2327.23 Torr / Autoclave

3: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 16 h / 120 °C

4: hydrogen / Heating

With copper(l) iodide; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; triethylamine; lithium hydroxide; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; 3: |Ullmann Condensation;
DOI:10.1016/j.bmcl.2015.01.038

Reference yield:

: 1400633-91-1
7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

: 1400633-81-9
6-(5-methylpyridin-2-yl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon; triethylamine / ethyl acetate; methanol / 16 h / 50 °C / 2327.23 Torr / Autoclave

2: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 16 h / 120 °C

3: hydrogen / Heating

With copper(l) iodide; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; In methanol; ethyl acetate; toluene; 2: |Ullmann Condensation;
DOI:10.1016/j.bmcl.2015.01.038