(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one
CAS No.:1402797-09-4
Molecular Formula:C₃₁H₃₃F₆N₃O₄
Molecular Weight:625.611
Hs Code.:

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Synonyms:(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

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Chemical Property of (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

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Technology Process of (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

There total 8 articles about (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 107-09-5
2-bromoethylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1422975-65-2
C₂₈H₃₀F₆N₂O₃

: 1402797-09-4
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: 2-bromoethylamine; C₂₈H₃₀F₆N₂O₃;

bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 107-09-5
2-bromoethylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: C₂₈H₂₈F₆N₂O₄

: 1402797-09-4
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 4255-62-3
4,4-dimethylcyclohexane-1-one

: 1402797-09-4
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-methoxy-5-(2-oxoimidazolidin-1-yl)phenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / dichloromethane

2.1: sodium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,2-dimethoxyethane; water / Microwave irradiation

3.1: nitric acid; acetic acid

4.1: sodium cyanoborohydride; acetic acid / dichloromethane

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane

6.1: methanol / Raney Ni

7.2: 20 °C

With methanol; nitric acid; phosphorus tribromide; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,2-dimethoxyethane; dichloromethane; water; 2.1: Suzuki Coupling;