4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

Base Information

Chemical Name:4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol
CAS No.:783342-12-1
Molecular Formula:C₄₀H₅₉FO₄Si₂
Molecular Weight:679.075
Hs Code.:

Synonyms:4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

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Chemical Property of 4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

Chemical Property:

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Technology Process of 4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

There total 10 articles about 4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3S,4R)-2-(4-Benzyloxy-phenyl)-5-fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman

: 4-[(2S,3S,4R)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

: 783342-12-1
4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1016/j.bmcl.2005.01.046

Reference yield:

: 783342-45-0
5-fluoro-6-hydroxy-3-(4-hydroxy-phenyl)-chromen-2-one

: 783342-12-1
4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: EtN(i-Pr)2 / dimethylformamide / 20 °C

2.1: DIBAL / CH₂Cl₂ / Cooling

3.1: CH₂Cl₂ / 20 °C

4.1: tetrahydrofuran; toluene / 50 °C

5.1: borane / tetrahydrofuran / 20 °C

5.2: 82 percent / aq. H₂O₂; Na₂CO₃ / tetrahydrofuran

6.1: 74 percent / KI; Bu₄NI; BF₃*Et₂O / CH₂Cl₂ / 0 °C

7.1: tetrahydrofuran / Cooling

8.1: H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With boron trifluoride diethyl etherate; borane; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 4.1: Grignard addition;
DOI:10.1016/j.bmcl.2005.01.046

Reference yield:

: 783342-27-8
5-fluoro-2-phenoxy-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-2H-chromene

: 783342-12-1
4-[(2R,3R,4S)-5-Fluoro-4-methyl-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; toluene / 50 °C

2.1: borane / tetrahydrofuran / 20 °C

2.2: 82 percent / aq. H₂O₂; Na₂CO₃ / tetrahydrofuran

3.1: 74 percent / KI; Bu₄NI; BF₃*Et₂O / CH₂Cl₂ / 0 °C

4.1: tetrahydrofuran / Cooling

5.1: H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With boron trifluoride diethyl etherate; borane; hydrogen; tetra-(n-butyl)ammonium iodide; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 1.1: Grignard addition;
DOI:10.1016/j.bmcl.2005.01.046