(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

Base Information

Chemical Name:(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide
CAS No.:1449736-01-9
Molecular Formula:C₂₈H₂₂ClF₄N₅O₃
Molecular Weight:587.961
Hs Code.:

Synonyms:(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

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Chemical Property of (S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

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Technology Process of (S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

There total 7 articles about (S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₆ClF₄N₅O

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1449736-01-9
(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 - 26 ℃; for 2h;

Reference yield:

: 19815-18-0
4-chloro-8-nitroquinazoline

: 1449736-01-9
(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 2 h / 120 °C / Sealed tube

2: iron; ammonium chloride / ethanol; water / 2 h / Reflux

3: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane

4: hydrogenchloride / methanol / 2 h / 22 - 26 °C

5: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 22 - 26 °C

With hydrogenchloride; oxalyl dichloride; iron; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 606-18-8
3-nitroanthranilic acid

: 1449736-01-9
(S)-N-(4-chloro-2-fluoro-3-((4-((3-(trifluoromethyl)phenyl)amino)quinazolin-8-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2 h / 150 °C / Sealed tube

2: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux

3: isopropyl alcohol / 2 h / 120 °C / Sealed tube

4: iron; ammonium chloride / ethanol; water / 2 h / Reflux

5: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane

6: hydrogenchloride / methanol / 2 h / 22 - 26 °C

7: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 22 - 26 °C

With hydrogenchloride; oxalyl dichloride; phosphorus pentachloride; iron; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;