N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

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Chemical Name:N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide
CAS No.:1027892-76-7
Molecular Formula:C₃₅H₃₅FN₆O₄S
Molecular Weight:654.765
Hs Code.:

Synonyms:N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

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Chemical Property of N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

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Technology Process of N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

There total 9 articles about N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1027892-76-7
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 7.6 g / Et₃N / tetrahydrofuran / 17 h / Heating

2: Et₃N / tetrahydrofuran / Heating

3: TFA / 12 h

With triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00015a016

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 1027892-76-7
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1: NBS, AIBN / CCl₄ / 4 h / Heating

2: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

3: 86 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 20 h / Heating

4: tetrahydrofuran / 1.5 h / Ambient temperature

5: MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

6: 7.6 g / Et₃N / tetrahydrofuran / 17 h / Heating

7: Et₃N / tetrahydrofuran / Heating

8: TFA / 12 h

With manganese(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1027892-76-7
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-isonicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

2: 86 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 20 h / Heating

3: tetrahydrofuran / 1.5 h / Ambient temperature

4: MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

5: 7.6 g / Et₃N / tetrahydrofuran / 17 h / Heating

6: Et₃N / tetrahydrofuran / Heating

7: TFA / 12 h

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016