C₄₄H₅₄N₈O₆S

Base Information

• Chemical Name: C₄₄H₅₄N₈O₆S
• CAS No.: 1335317-13-9
• Molecular Formula: C₄₄H₅₄N₈O₆S
• Molecular Weight: 823.029
• Mol file: 1335317-13-9.mol

Synonyms:C₄₄H₅₄N₈O₆S

Chemical Property of C₄₄H₅₄N₈O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₄N₈O₆S

There total 14 articles about C₄₄H₅₄N₈O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-((2S,4S)-4-methylpyrrolidin-2-yl)-5-(4'-(2-((2S,4S)-4-methylpyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-thieno[2,3-d]imidazole tritrifluoroacetate + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C44H54N8O6S (1335317-13-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

(2S,4S)-tert-butyl 2-(5-((4-bromophenyl)ethynyl)-4-iodo-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate (1335317-49-1) → C44H54N8O6S (1335317-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodiumsulfide nonahydrate / N,N-dimethyl-formamide / 3 h / 20 - 150 °C

2: sodium hydrogencarbonate / palladium diacetate / isopropyl alcohol; water / 15 h / 100 °C / Inert atmosphere

3: dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With sodiumsulfide nonahydrate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

(2S,4S)-tert-butyl 2-(5-(4-bromophenyl)-1H-thieno[2,3-d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate (1335317-50-4) → C44H54N8O6S (1335317-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / palladium diacetate / isopropyl alcohol; water / 15 h / 100 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

4-bromo-1-ethynylbenzene

N-methoxycarbonyl-L-valine

(2S,4S)-tert-butyl 2-(5-(4-bromophenyl)-1H-thieno[2,3-d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

(2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate