2-(3-Fluoro-4-isobutoxyphenyl)acetic acid

Base Information

Chemical Name:2-(3-Fluoro-4-isobutoxyphenyl)acetic acid
CAS No.:127437-33-6
Molecular Formula:C₁₂H₁₅FO₃
Molecular Weight:226.248
Hs Code.:
DSSTox Substance ID:DTXSID201246784

Synonyms:2-(3-Fluoro-4-isobutoxyphenyl)acetic acid;127437-33-6;2-[3-fluoro-4-(2-methylpropoxy)phenyl]acetic acid;Benzeneacetic acid, 3-fluoro-4-(2-methylpropoxy)-;DTXSID201246784;3-Fluoro-4-(2-methylpropoxy)benzeneacetic acid;A1-21703

Suppliers and Price of 2-(3-Fluoro-4-isobutoxyphenyl)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Fluoro-4-isobutoxyphenyl)acetic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:226.10052250
Heavy Atom Count:16
Complexity:230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)COC1=C(C=C(C=C1)CC(=O)O)F

Technology Process of 2-(3-Fluoro-4-isobutoxyphenyl)acetic acid

There total 8 articles about 2-(3-Fluoro-4-isobutoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78-77-3
Isobutyl bromide

: 458-09-3
(3-fluoro-4-hydroxyphenyl)acetic acid

: 127437-33-6
(3-Fluoro-4-isobutoxy-phenyl)-acetic acid

Guidance literature:: (3-fluoro-4-hydroxyphenyl)acetic acid; With sulfuric acid; In methanol; for 1.5h;

Isobutyl bromide; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 16h;

Reference yield:

: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid methyl ester

: 127437-33-6
(3-Fluoro-4-isobutoxy-phenyl)-acetic acid

Guidance literature:: With potassium hydroxide; water; In ethanol; for 8h; Yield given; Heating;

Reference yield:

: 458-09-3
(3-fluoro-4-hydroxyphenyl)acetic acid

: 127437-33-6
(3-Fluoro-4-isobutoxy-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / HCl / 6 h / Heating

2: 1.) NaOMe / 1.) MeOH, 20 deg C, 15 min, 2.) DMSO, 100 deg C, 6 h

3: H₂O, KOH / ethanol / 8 h / Heating

With hydrogenchloride; potassium hydroxide; water; sodium methylate; In ethanol;