6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

Base Information

Chemical Name:6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline
CAS No.:494868-87-0
Molecular Formula:C₂₃H₂₄ClNO₄
Molecular Weight:413.901
Hs Code.:

Synonyms:6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

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Chemical Property of 6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

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Technology Process of 6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

There total 10 articles about 6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4-benzyloxy-7-bromo-6-[N-(3-chloro-2-propenyl)-N-(tert-butyloxycarbonyl)amino]benzofuran

: 494868-87-0
6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 100 - 110 ℃; for 3h;
DOI:10.1016/j.tetlet.2014.04.062

Reference yield: 48.0%

: 4-benzyloxy-7-bromo-6-[N-(3-chloro-2-propenyl)-N-(tert-butyloxycarbonyl)amino]benzofuran

: 494868-86-9
5-benzyloxy-3-(tert-butoxycarbonyl)-1-chloromethyl-1,2-dihydro-3H-furano[2,3-e]indole

: 494868-87-0
6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃; for 2h;
DOI:10.1016/S0968-0896(02)00157-8

Reference yield:

: 494868-82-5
4-hydroxybenzofuran-6-carboxylic acid ethyl ester

: 494868-87-0
6-benzyloxy-4-(tert-butoxycarbonyl)-2-chloro-1,2,3,4-tetrahydro-4H-furano[2,3-f]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / K₂CO₃; Bu₄NI / dimethylformamide

2.1: 93 percent / 10 percent NaOH / ethanol / 3 h / Heating

3.1: 100 percent / diphenylphosphorylazide; 3 Angstroem molecular sieves; Et₃N / Heating

4.1: 55 percent / N-bromosuccinimide; p-toluenesulfonic acid / tetrahydrofuran; methanol / 2 h / -78 °C

5.1: NaH / dimethylformamide / 0.75 h / 0 °C

5.2: 45 percent / dimethylformamide

6.1: AIBN; nBu₃SnH / toluene

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; diphenylphosphoranyl azide; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(02)00157-8