(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

Base Information

Chemical Name:(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman
CAS No.:888026-42-4
Molecular Formula:C₅₀H₅₈O₇
Molecular Weight:771.006
Hs Code.:

Synonyms:(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

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Chemical Property of (2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

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Technology Process of (2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

There total 9 articles about (2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 888026-48-0
(2R,3S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman-3-yl O-phenylcarbonothioate

: 888026-42-4
(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 100 ℃; for 6h;
DOI:10.1021/ol060511b

Reference yield:

: 850816-16-9
(2R,3S)-2-(4-benzyloxyphenyl)-7-benzyloxychroman-3-ol

: 888026-42-4
(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 82 percent / DDQ; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

3: 75 percent / TMSOTf / CH₂Cl₂ / 1 h / 0 °C

4: 92 percent / potassium carbonate / tetrahydrofuran; methanol / 48 h / 20 °C

5: 76 percent / 4-(dimethylamino)pyridine / acetonitrile / 24 h / 50 °C

6: 95 percent / SnBu₃H; AIBN / toluene / 6 h / 100 °C

With dmap; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol060511b

Reference yield:

: 888026-43-5
(2R,3S)-7-(benzoxy)-2-(4-(benzoxy)phenyl)chroman-3-yl acetate

: 888026-42-4
(2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / DDQ; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

2: 75 percent / TMSOTf / CH₂Cl₂ / 1 h / 0 °C

3: 92 percent / potassium carbonate / tetrahydrofuran; methanol / 48 h / 20 °C

4: 76 percent / 4-(dimethylamino)pyridine / acetonitrile / 24 h / 50 °C

5: 95 percent / SnBu₃H; AIBN / toluene / 6 h / 100 °C

With dmap; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol060511b