N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

Base Information

Chemical Name:N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine
CAS No.:1459257-81-8
Molecular Formula:C₃₇H₃₆N₆O
Molecular Weight:580.732
Hs Code.:

Synonyms:N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

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Technology Process of N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

There total 6 articles about N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 110-91-8,99108-56-2
morpholine

: 1459257-80-7
3-(4-chloropyridin-2-yl)-N-isopropyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

: 1459257-81-8
N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1459257-78-3
N-isopropyl-3-(trimethylstannyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

: 1459257-81-8
N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 2 h / 160 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium chloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1186647-69-7
4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine

: 1459257-81-8
N-isopropyl-3-(4-morpholinopyridin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

1.2: 3 h

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

3.1: trans-bis(triphenylphosphine)palladium dichloride / toluene / 0.5 h / 140 °C / Inert atmosphere

4.1: lithium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 2 h / 160 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; butan-1-ol;