tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate

Base Information

• Chemical Name: tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate
• CAS No.: 1097104-22-7
• Molecular Formula: C₂₅H₃₁NO₆
• Molecular Weight: 441.524

Synonyms:tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate

Chemical Property of tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate

There total 1 articles about tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-33-8) + methyl (2-hydroxyphenyl)acetate (22446-37-3) → tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate (1097104-22-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm800817h

Reference yield: 64.0%

tert-butyl (2S,3S)-2-[α-(2-(2-methoxy-2-oxoethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate (1097104-22-7) → tert-butyl (2S,3S)-2-[α-(2-(2-hydroxyethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate (1097104-26-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm800817h

upstream raw materials:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

methyl (2-hydroxyphenyl)acetate

Downstream raw materials:

tert-butyl (2S,3S)-2-[α-(2-(2-hydroxyethyl)phenoxy)(phenyl)methyl]morpholine-4-carboxylate

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