C₃₅H₃₇N₅

Base Information

• Chemical Name: C₃₅H₃₇N₅
• CAS No.: 1304723-52-1
• Molecular Formula: C₃₅H₃₇N₅
• Molecular Weight: 527.712
• Mol file: 1304723-52-1.mol

Synonyms:C₃₅H₃₇N₅

Chemical Property of C₃₅H₃₇N₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₇N₅

There total 8 articles about C₃₅H₃₇N₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzophenoneimine + C22H27ClN4 (1304723-51-0) → C35H37N5 (1304723-52-1)

Guidance literature:

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; at 95 ℃; for 7h;

DOI:10.1016/j.bmcl.2011.02.098

Reference yield:

4,6-dichloro-5-cyclopropylpyrimidine (832754-14-0) → C35H37N5 (1304723-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 80 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / 7 h / 95 °C

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In 1-methyl-pyrrolidin-2-one; 2: Buchwald coupling;

DOI:10.1016/j.bmcl.2011.02.098

Reference yield:

2,7-diazaspiro[4.5]decane-7-carboxylic acid tert-butyl ester → C35H37N5 (1304723-52-1)

Guidance literature:

Multi-step reaction with 6 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane

3: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; water / 36 h / Reflux

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 80 °C

6: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / 7 h / 95 °C

With hydrogenchloride; palladium diacetate; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; 6: Buchwald coupling;

DOI:10.1016/j.bmcl.2011.02.098

upstream raw materials:

C₂₂H₂₇ClN₄

4,6-dichloro-5-cyclopropylpyrimidine

(S)-7-benzyl-2,7-diazaspiro[4.5]decane

benzaldehyde

Downstream raw materials:

C₂₂H₂₉N₅

C₃₀H₄₆N₆O₄S

C₂₉H₄₂N₆O₃S

C₂₉H₄₂N₆O₃S