Propylamine, 1,1,2,2-tetramethyl-, hydrochloride

Base Information

• Chemical Name: Propylamine, 1,1,2,2-tetramethyl-, hydrochloride
• CAS No.: 29772-54-1
• Molecular Formula: C7H17 N
• Molecular Weight: 115.219
• DSSTox Substance ID: DTXSID50183918
• Wikidata: Q83054778
• Mol file: 29772-54-1.mol

Synonyms:2,3,3-trimethylbutan-2-amine;29772-54-1;Propylamine, 1,1,2,2-tetramethyl-, hydrochloride;2,2,3-Trimethyl-3-aminobutane hydrochloride;1,1,2,2-Tetramethylpropylamine hydrochloride;SCHEMBL869782;2,3,3-trimethyl-2-butylamine;DTXSID50183918;AKOS005216078;LS-125736;(1,1,2,2-Tetramethylpropyl)amine, AldrichCPR;EN300-221796

Chemical Property of Propylamine, 1,1,2,2-tetramethyl-, hydrochloride

Chemical Property:

• Vapor Pressure: 17mmHg at 25°C
• Boiling Point: 118°C at 760 mmHg
• Flash Point: 19°C
• PSA: 26.02000
• Density: 0.779g/cm³
• LogP: 2.47010
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 115.136099547
• Heavy Atom Count: 8
• Complexity: 76.9

Purity/Quality:

(1,1,2,2-tetramethylpropyl)aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(C)(C)N

Technology Process of Propylamine, 1,1,2,2-tetramethyl-, hydrochloride

There total 7 articles about Propylamine, 1,1,2,2-tetramethyl-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(2,3,3-trimethylbutan-2-yl)acetamide (39198-35-1) → 2,3,3-trimethylbutan-2-amine (29772-54-1)

Guidance literature:

With potassium hydroxide; at 200 ℃; for 24h;

DOI:10.1021/jo00323a021

Reference yield:

2,3,3-trimethyl-2-butanol (594-83-2) → 2,3,3-trimethylbutan-2-amine (29772-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / H₂SO₄ / acetic acid / 12 h / Ambient temperature

2: 86 percent / aq. KOH / 24 h / 200 °C

With potassium hydroxide; sulfuric acid; In acetic acid;

DOI:10.1021/jo00323a021

Reference yield:

(1,1,2,2-tetramethyl-propyl)-carbamic acid methyl ester (100792-21-0) → 2,3,3-trimethylbutan-2-amine (29772-54-1)

Guidance literature:

With methanol; sodium hydroxide;

DOI:10.1021/ja01515a054

upstream raw materials:

N-(1,1,2,2-tetramethylpropyl)formamide

(1,1,2,2-tetramethyl-propyl)-carbamic acid methyl ester

N-(2,3,3-trimethylbutan-2-yl)acetamide

N-(1,1,2,2-Tetramethyl)propylharnstoff

Downstream raw materials:

N-(2.6-Diisopropyl-phenyl)-N'-(1.1.2.2-tetramethyl-propyl)-thioharnstoff

Refernces

• 1、 Liu, Xiang,Ge, Kaiqi,Guan, Pei,He, Pang,Li, Yunfei,Shi, Yanhui,Cao, Changsheng. "Synthesis of anovel sterically hindered imidazolinium chloride: An N-heterocyclic carbene precursor". . p. 288 - 289. Retrieved 2012.
• 2、 VEJDELEK,TRCKA. "Substituted tert-hexylamines as newer type of hypotensive compound.". . p. 215 - 216. Retrieved 2007/10/05.