Technology Process of (S)-1-(2'-bromocyclohex-2'-enyl)pentan-1-one
There total 3 articles about (S)-1-(2'-bromocyclohex-2'-enyl)pentan-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / -5 °C / Inert atmosphere
2: pyridine; dmap / diethyl ether / 1.33 h / 2 - 20 °C / Inert atmosphere
3: Candida lipase OF; water / 25 h / 20 °C / pH 7 / aq. phosphate buffer; Inert atmosphere; Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere
With
pyridine; dmap; Candida lipase OF; water; ammonium chloride; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tet.2010.11.035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / -5 °C / Inert atmosphere
2: pyridine; dmap / diethyl ether / 1.33 h / 2 - 20 °C / Inert atmosphere
3: Candida lipase OF; water / 25 h / 20 °C / pH 7 / aq. phosphate buffer; Inert atmosphere; Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere
With
pyridine; dmap; Candida lipase OF; water; ammonium chloride; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tet.2010.11.035
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Candida lipase OF; water / 25 h / 20 °C / pH 7 / aq. phosphate buffer; Inert atmosphere; Enzymatic reaction
2: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere
With
Candida lipase OF; water; pyridinium chlorochromate;
In
dichloromethane;
DOI:10.1016/j.tet.2010.11.035
