(S)-3-amino-4-phenylbutanoic acid trifluoroacetate

Base Information

• Chemical Name: (S)-3-amino-4-phenylbutanoic acid trifluoroacetate
• CAS No.: 114645-20-4
• Molecular Formula: C₂HF₃O₂*C₁₀H₁₃NO₂
• Molecular Weight: 293.243
• Mol file: 114645-20-4.mol

Synonyms:(S)-3-amino-4-phenylbutanoic acid trifluoroacetate

Chemical Property of (S)-3-amino-4-phenylbutanoic acid trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-amino-4-phenylbutanoic acid trifluoroacetate

There total 3 articles about (S)-3-amino-4-phenylbutanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid (51871-62-6) + trifluoroacetic acid (76-05-1) → (S)-3-amino-4-phenylbutanoic acid trifluoroacetate (114645-20-4)

Guidance literature:

for 0.25h;

DOI:10.1016/S0040-4020(01)81643-4

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-3-amino-4-phenylbutanoic acid trifluoroacetate (114645-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Isobutyl chloroformate, triethylamine / 1.) diethyl ether, -20 deg C , 15 min 2.) diethyl ether, 1 h at -10 deg C then 12 h at 5 deg C

2: 1.) Ag₂O, Na₂S₂O₃, anh. Na₂CO₃ 2.) 0.1N HCl / 1.) water, dioxane, 81-85 deg C, 1.5 h 2.) water, 5 deg C

3: 85 percent / 0.25 h

With hydrogenchloride; sodium carbonate; sodium thiosulfate; triethylamine; silver(l) oxide; isobutyl chloroformate;

DOI:10.1016/S0040-4020(01)81643-4

Reference yield:

(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate (60398-41-6) → (S)-3-amino-4-phenylbutanoic acid trifluoroacetate (114645-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Ag₂O, Na₂S₂O₃, anh. Na₂CO₃ 2.) 0.1N HCl / 1.) water, dioxane, 81-85 deg C, 1.5 h 2.) water, 5 deg C

2: 85 percent / 0.25 h

With hydrogenchloride; sodium carbonate; sodium thiosulfate; silver(l) oxide;

DOI:10.1016/S0040-4020(01)81643-4

upstream raw materials:

(S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid

trifluoroacetic acid

N-tert-butoxycarbonyl-L-phenylalanine

(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate

Downstream raw materials:

(S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid