Technology Process of C15H10ClF3N4O
There total 5 articles about C15H10ClF3N4O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C17H12ClF3N4O2;
With
sulfuric acid; water;
at 85 ℃;
for 5h;
Inert atmosphere;
With
sodium hydroxide;
In
water;
at 20 ℃;
pH=8 - 9;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.05.051
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C
2.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere
2.2: 20 h / 85 °C / Inert atmosphere
3.1: sulfuric acid; water / 5 h / 85 °C / Inert atmosphere
3.2: 20 °C / pH 8 - 9 / Inert atmosphere
With
sulfuric acid; ammonium acetate; water; sodium methylate; potassium carbonate;
In
propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C
1.2: 1 h / 7 °C
2.1: triethylamine; trifluoroacetic anhydride / ethyl acetate / 1.25 h / -5 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C
4.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere
4.2: 20 h / 85 °C / Inert atmosphere
5.1: sulfuric acid; water / 5 h / 85 °C / Inert atmosphere
5.2: 20 °C / pH 8 - 9 / Inert atmosphere
With
thionyl chloride; sulfuric acid; ammonium acetate; water; sodium methylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride;
In
propan-1-ol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051
