4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Base Information

Chemical Name:4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide
CAS No.:957147-17-0
Molecular Formula:C₂₆H₃₂F₃N₃OSi
Molecular Weight:487.64
Hs Code.:

Synonyms:4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Suppliers and Price of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

There total 10 articles about 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 943320-50-1
3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide

: 1066-54-2
trimethylsilylacetylene

: 957147-17-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield:

: 694499-26-8
4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

: 957147-17-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / -20 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jm301581y

Reference yield:

: 52107-98-9
3-iodo-4-methylbenzoyl chloride

: 957147-17-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 4 h / 20 °C

2: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / toluene / 24 h / 58 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; toluene;