C₁₄H₁₉BrO₃

Base Information

• Chemical Name: C₁₄H₁₉BrO₃
• CAS No.: 1391635-45-2
• Molecular Formula: C₁₄H₁₉BrO₃
• Molecular Weight: 315.207
• Mol file: 1391635-45-2.mol

Synonyms:C₁₄H₁₉BrO₃

Chemical Property of C₁₄H₁₉BrO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₄H₁₉BrO₃

There total 1 articles about C₁₄H₁₉BrO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H28O3Si → C14H19BrO3 (1391635-45-2)

Guidance literature:

With bromine; sodium methylate; In methanol; dichloromethane; at -78 - -20 ℃; for 4h;

DOI:10.1002/anie.201201323

Reference yield: 88.0%

C14H19BrO3 (1391635-45-2) + bis(trimethylsilyl)methylmagnesium chloride (86509-05-9) → C21H38O3Si2 (1391635-46-3)

Guidance literature:

C₁₄H₁₉BrO₃; With methylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

bis(trimethylsilyl)methylmagnesium chloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 - 40 ℃; for 10.25h; Inert atmosphere;

DOI:10.1002/anie.201201323

Reference yield:

C14H19BrO3 (1391635-45-2) → C29H52O4Si2

Guidance literature:

Multi-step reaction with 2 steps

1.1: methylmagnesium chloride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 0.08 h / 0 - 25 °C / Inert atmosphere

1.3: 10.25 h / 25 - 40 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 1 h / -78 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; methylmagnesium chloride; In tetrahydrofuran; diethyl ether; 1.1: |Kumada Cross-Coupling / 1.2: |Kumada Cross-Coupling / 1.3: |Kumada Cross-Coupling;

DOI:10.1021/acs.orglett.7b02510

Downstream raw materials:

C₂₁H₃₈O₃Si₂