3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

Base Information

Chemical Name:3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile
CAS No.:67983-24-8
Molecular Formula:C₃₁H₄₃NO₅Si
Molecular Weight:537.772
Hs Code.:

Synonyms:3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

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Chemical Property of 3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

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Technology Process of 3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

There total 1 articles about 3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 16750-63-3
2-methoxyphenylmagnesium bromide

: 33403-21-3
3,3-ethylendioxy-5α,10α-epoxy-17α-(trimethylsilyloxy)-estr-9(11)-en-17β-carbonitrile

: 67983-24-8
3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

Guidance literature:: With copper(l) chloride; In tetrahydrofuran; at -10 ℃; for 1h;
DOI:10.1016/0039-128X(81)90039-8

Reference yield:

: 67983-24-8
3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

: 68159-30-8
17-ethynyl-11β-o-methoxyphenyl-1,3,5(10)-estratriene-3,17β-diol

Guidance literature:: Multi-step reaction with 3 steps

1: ethylenediamine / 45 - 50 °C

2: sulfonic resin "Redex CF" / aq. ethanol / Heating

3: 1) Ac₂O, AcBr, 2) 10N NaOH / 1) CH₂Cl₂, 0 deg C, 2) MeOH, r.t.

With sodium hydroxide; Acetyl bromide; sulfonic resin "Redex CF"; acetic anhydride; ethylenediamine; In ethanol;
DOI:10.1016/0039-128X(81)90039-8

Reference yield:

: 67983-24-8
3,3-ethylenedioxy-5-hydroxy-11β-o-methoxyphenyl-17-trimethylsilyloxy-5α-estr-9-ene-17β-carbonitrile

: 67983-57-7
17-ethynyl-17β-hydroxy-11β-o-methoxyphenyl-4,9-estradien-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethylenediamine / 45 - 50 °C

2: sulfonic resin "Redex CF" / aq. ethanol / Heating

With sulfonic resin "Redex CF"; ethylenediamine; In ethanol;
DOI:10.1016/0039-128X(81)90039-8