N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine
CAS No.:1346521-97-8
Molecular Formula:C₂₁H₂₉N₅O₆
Molecular Weight:447.491
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Suppliers and Price of N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

There total 3 articles about N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1346521-94-5
benzyl N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alaninate

: 1346521-97-8
N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1.5h; under 1034.32 Torr;
DOI:10.1021/ol202767k

Reference yield:

: 145967-50-6
benzyl (2S)-3-azido-2-[(tert-butoxycarbonyl)amino]propanoate

: 1346521-97-8
N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C / 1034.32 Torr

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol;
DOI:10.1021/ol202767k

Reference yield:

: 1360151-55-8
C₁₃H₁₅NO₂

: 1346521-97-8
N-(tert-butoxycarbonyl)-3-{5-[((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)methyl]-1H-1,2,3-triazol-1-yl}-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C / 1034.32 Torr

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol;
DOI:10.1021/ol202767k