α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

Base Information

Chemical Name:α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid
CAS No.:569351-96-8
Molecular Formula:C₅₇H₅₆Cl₃NO₁₃S
Molecular Weight:1101.5
Hs Code.:

Synonyms:α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

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Chemical Property of α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

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Technology Process of α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

There total 7 articles about α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 569351-93-5
3-((((9H-fluoren-9-yl)-methoxy)-carbonyl)-amino)-4-oxo-4-(2,2,2-trichloroethoxy)-butanoic acid

: 569351-95-7
phenyl 2,3,4-tri-O-4-methoxybenzyl-1-thio-α-D-mannopyranoside

: 569351-96-8
α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1016/S0957-4166(03)00118-6

Reference yield:

: 2936-70-1,5624-48-6,13992-15-9,16758-34-2,28244-97-5,77481-63-1,105088-17-3,149495-84-1,77481-62-0
(2R,3S,4S,5S,6R)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol

: 569351-96-8
α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 197 mg / imidazole / dimethylformamide / 0.42 h / -20 °C

2: 60 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 18 h / Heating

3: 79 percent / tetrabutylammonium fluoride / diethyl ether / 10 h / 0 °C

4: 72 percent / dimethylaminopyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 7 h / 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(03)00118-6

Reference yield:

: 13992-16-0,23661-28-1,24404-53-3,28512-68-7,65236-85-3,86782-39-0,121524-01-4,121570-34-1,108032-93-5
phenyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-mannopyranoside

: 569351-96-8
α-2,2,2-trichloroethyl-β-carboxy-(phenyl 2,3,4-tri-O-4-methoxybenzyl-α-D-mannopyranos-6-O-yl)-N-9-fluorenylmethoxycarbonyl-L-aspartic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Na; MeOH / 0 - 20 °C

2: 197 mg / imidazole / dimethylformamide / 0.42 h / -20 °C

3: 60 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 18 h / Heating

4: 79 percent / tetrabutylammonium fluoride / diethyl ether / 10 h / 0 °C

5: 72 percent / dimethylaminopyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 7 h / 20 °C

With 1H-imidazole; methanol; dmap; tetrabutyl ammonium fluoride; sodium; tetra-(n-butyl)ammonium iodide; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(03)00118-6