(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Base Information

Chemical Name:(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal
CAS No.:148933-73-7
Molecular Formula:C₄₄H₇₀O₇Si
Molecular Weight:739.121
Hs Code.:

Synonyms:(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Suppliers and Price of (E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

There total 25 articles about (E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 148933-87-3
(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dien-1-ol

: 148933-73-7
(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - -10 ℃; for 1h;
DOI:10.1039/c39930000619

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 148933-73-7
(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / CSA / CH₂Cl₂ / 4 h / 25 °C

2: 96 percent / DIBALH / CH₂Cl₂ / 2 h / 25 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) r.t., 90 min

4: 57 percent / CrCl₂, NiCl₂ / dimethylsulfoxide / 72 h / 25 °C

5: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

6: 97 percent / HF*pyridine / tetrahydrofuran / 12 h / 25 °C

7: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) 0 deg C, 3 h

With 2,6-dimethylpyridine; chromium dichloride; oxalyl dichloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; pyridine hydrogenfluoride; dimethyl sulfoxide; triethylamine; nickel dichloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 168777-81-9
(3S,4R)-1-[(tert-butyldimethylsilyl)oxy]-4-methylhex-5-en-3-ol

: 148933-73-7
(E)-(3S,4R,7R,8S,9R,10R,12S)-8-Methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-7-triisopropylsilanyloxy-tetradeca-5,13-dienal

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 2.5 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, pyridine, -78 deg C, 2.) 25 deg C, 16h

3: 1.) Zn, Ph₃P / 1.) CH₂Cl₂, 25 deg C, 24 h, 2.) 25 deg C, 2 h

4: 1.) n-BuLi / 1.) THF, hexane, -78 to -20 deg C; -20 deg C, 1 h, 2.) 0 deg C, 2 h

5: 1.) Cp₂ZrHCl, 2.) I₂ / 1.) CH₂Cl₂, 25 deg C, 90 min, 2.) CCl₄, 0 deg C

6: 57 percent / CrCl₂, NiCl₂ / dimethylsulfoxide / 72 h / 25 °C

7: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

8: 97 percent / HF*pyridine / tetrahydrofuran / 12 h / 25 °C

9: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) 0 deg C, 3 h

With 2,6-dimethylpyridine; chromium dichloride; Schwartz's reagent; n-butyllithium; oxalyl dichloride; dimethylsulfide; iodine; sodium hexamethyldisilazane; pyridine hydrogenfluoride; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; nickel dichloride; zinc; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;