(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

Base Information

Chemical Name:(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran
CAS No.:292069-11-5
Molecular Formula:C₂₂H₂₈O₃Si
Molecular Weight:368.548
Hs Code.:

Synonyms:(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

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Technology Process of (2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

There total 6 articles about (2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 292069-13-7
(2S,5S)-2,5-di[(tert-butyldiphenylsilyl)oxymethyl]-2,5-dihydrofuran

: 292069-11-5
(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 46.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 292069-09-1
(2S,5S)-2,5-di(hydroxymethyl)-2,5-dihydrofuran

: 292069-11-5
(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

: 292069-13-7
(2S,5S)-2,5-di[(tert-butyldiphenylsilyl)oxymethyl]-2,5-dihydrofuran

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; acetonitrile; at -78 ℃; for 1h;

Reference yield:

: 41107-82-8
2,5-anhydro-D-mannitol

: 292069-11-5
(2S,5S)-2-[(tert-butyldiphenylsilyl)oxymethyl]-5-hydroxymethyl-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / 7 h / 20 °C

2: 39 percent / pyridine / 13 h / 0 - 20 °C

3: 84 percent / zinc powder; NaI / dimethylformamide / 19 h / 140 °C

4: 92 percent / acetic acid; H₂O / 2 h / 50 °C

5: 46 percent / imidazole / acetonitrile; tetrahydrofuran / 1 h / -78 °C

With pyridine; 1H-imidazole; sodium iodide; zinc; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: Etherification / 3: Reduction / 4: deetherification / 5: Etherification;