(6E)-6-{5-methyl-6-[(2-morpholin-4-ylethyl)amino]pyridazin-3(2H)-ylidene}cyclohexa-2,4-dien-1-one dihydrobromide

Base Information

Chemical Name:(6E)-6-{5-methyl-6-[(2-morpholin-4-ylethyl)amino]pyridazin-3(2H)-ylidene}cyclohexa-2,4-dien-1-one dihydrobromide
CAS No.:118269-98-0
Molecular Formula:2BrH*C₁₇H₂₂N₄O₂
Molecular Weight:476.211
Hs Code.:

Synonyms:3-<(β-Morpholinoethyl)amino>-4-methyl-6-(2-hydroxyphenyl)pyridazine dihydrobromide

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Chemical Property of (6E)-6-{5-methyl-6-[(2-morpholin-4-ylethyl)amino]pyridazin-3(2H)-ylidene}cyclohexa-2,4-dien-1-one dihydrobromide

Chemical Property:

Vapor Pressure:1.35E-09mmHg at 25°C

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Technology Process of (6E)-6-{5-methyl-6-[(2-morpholin-4-ylethyl)amino]pyridazin-3(2H)-ylidene}cyclohexa-2,4-dien-1-one dihydrobromide

There total 5 articles about (6E)-6-{5-methyl-6-[(2-morpholin-4-ylethyl)amino]pyridazin-3(2H)-ylidene}cyclohexa-2,4-dien-1-one dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 118269-95-7
[6-(2-Methoxy-phenyl)-4-methyl-pyridazin-3-yl]-(2-morpholin-4-yl-ethyl)-amine; hydrochloride

: 118269-98-0
3-<(β-Morpholinoethyl)amino>-4-methyl-6-(2-hydroxyphenyl)pyridazine dihydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; for 6h; Heating;
DOI:10.1021/jm00123a004

Reference yield:

: 579-74-8
2-Methoxyacetophenone

: 118269-98-0
3-<(β-Morpholinoethyl)amino>-4-methyl-6-(2-hydroxyphenyl)pyridazine dihydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: KOH / methanol; H₂O / 96 h / 4 °C

2: hydrazine hydrate / butan-1-ol / Heating

3: POCl₃ / 80 °C

5: 78 percent / conc. aq. HBr / acetic acid / 6 h / Heating

With potassium hydroxide; hydrogen bromide; hydrazine hydrate; trichlorophosphate; In methanol; water; acetic acid; butan-1-ol;
DOI:10.1021/jm00123a004

Reference yield:

: 29242-34-0
2-Hydroxy-4-(2-methoxy-phenyl)-2-methyl-4-oxo-butyric acid

: 118269-98-0
3-<(β-Morpholinoethyl)amino>-4-methyl-6-(2-hydroxyphenyl)pyridazine dihydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / butan-1-ol / Heating

2: POCl₃ / 80 °C

4: 78 percent / conc. aq. HBr / acetic acid / 6 h / Heating

With hydrogen bromide; hydrazine hydrate; trichlorophosphate; In acetic acid; butan-1-ol;
DOI:10.1021/jm00123a004