5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole
CAS No.:1430746-06-7
Molecular Formula:C₂₃H₂₉F₃N₄O₅S
Molecular Weight:530.568
Hs Code.:

5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

Synonyms:5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

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Chemical Property of 5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

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Technology Process of 5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

There total 1 articles about 5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.3%

: 4314-35-6
(Z)-2,2,2-trifluoro-N'-hydroxyacetimidamide

: 1430746-23-8
(1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyidin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carbonitrile

: 1430746-06-7
5-((1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethytl)-1,2,4-oxadiazole

Guidance literature:: (Z)-2,2,2-trifluoro-N'-hydroxyacetimidamide; (1R,3s,5S)-3-((1r,4R)-4-(2-methyl-6-(methylsulfonyl)pyidin-3-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carbonitrile; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 120 ℃; for 8h; Inert atmosphere; Microwave irradiation;