{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester

Base Information

• Chemical Name: {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester
• CAS No.: 122899-96-1
• Molecular Formula: C₂₉H₄₂N₃O₈P
• Molecular Weight: 591.642

Synonyms:{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester

Chemical Property of {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester

Chemical Property:

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Technology Process of {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester

There total 2 articles about {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(Diethoxy-phosphorylamino)-4-methyl-pentanoic acid benzyl ester → {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester (122899-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 760 Torr

2: 1-hydroxybenzotriazole, DCC / dimethylformamide / 10 h / 4 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a044

Reference yield:

H-Tyr(OBzl)-Gly-OMe (51482-07-6) + N--L-leucine (122899-91-6) → {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester (122899-96-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃; for 10h;

DOI:10.1021/jm00163a044

Reference yield:

{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid methyl ester (122899-96-1) → {(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

DOI:10.1021/jm00163a044

upstream raw materials:

H-Tyr(OBzl)-Gly-OMe

N--L-leucine

Downstream raw materials:

Potassium; {(S)-3-(4-benzyloxy-phenyl)-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

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