(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Chemical Name:(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester
CAS No.:155530-51-1
Molecular Formula:C₂₇H₃₄ClNO₄Si
Molecular Weight:500.11
Hs Code.:

Synonyms:(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Chemical Property of (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Technology Process of (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

There total 9 articles about (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 155530-48-6
(5R)-5-(tert-butyldiphenylsilanyloxymethyl)-4,5-dihydropyrrole-1,3-dicarboxylic acid 1-tert-butyl ester

: 155530-51-1
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With oxalyl dichloride; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)75792-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 155530-51-1
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / DMAP; triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: HMDS; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 99 percent / tetrahydrofuran; hexane / 0.75 h / -78 - 20 °C

3.1: 90 percent / H₂ / Pd/C / ethyl acetate / 22 h

4.1: 84 percent / NaBH₄ / HCl / ethanol / 1.47 h / -10 °C

5.1: oxalyl chloride / CH₂Cl₂ / 20 °C

With dmap; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; hydrogen; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate;
DOI:10.1021/ja0202964

Reference yield:

: 66673-40-3
(R)-5-hydroxymethylpyrrolidin-2-one

: 155530-51-1
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-chlorocarbonyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / imidazole / dimethylformamide / 5 h / 20 °C

2.1: 93 percent / DMAP; triethylamine / CH₂Cl₂ / 0 - 20 °C

3.1: HMDS; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 99 percent / tetrahydrofuran; hexane / 0.75 h / -78 - 20 °C

4.1: 90 percent / H₂ / Pd/C / ethyl acetate / 22 h

5.1: 84 percent / NaBH₄ / HCl / ethanol / 1.47 h / -10 °C

6.1: oxalyl chloride / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; hydrogen; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0202964