(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Base Information

Chemical Name:(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide
CAS No.:1613639-37-4
Molecular Formula:C₂₀H₁₆ClN₅O
Molecular Weight:377.833
Hs Code.:

Synonyms:(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

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Chemical Property of (S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Chemical Property:

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Technology Process of (S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

There total 5 articles about (S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613639-49-8
3-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole

: 1613639-39-6
(R)-5-(2-hydroxy-1-phenylethyl)aminopyridin-3-yl-boronic acid

: 1613639-36-3
(R)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

: 1613639-37-4
(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613639-36-3
(R)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

: 1613639-37-4
(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2.1: bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

2.2: 1 h / 100 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 90 °C / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; bis(pinacol)diborane; L-proline; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-36-3
(R)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

: 1613639-37-4
(S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2.1: bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 120 °C / Microwave irradiation; Inert atmosphere

2.2: 1 h / 100 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 90 °C / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; bis(pinacol)diborane; L-proline; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide;