(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Base Information

Chemical Name:(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid
CAS No.:527758-08-3
Molecular Formula:C₁₁H₁₀N₂O₃
Molecular Weight:218.212
Hs Code.:
Mol file:527758-08-3.mol

Synonyms:(E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Suppliers and Price of (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Chemical Property:

Boiling Point:419.6±55.0 °C(Predicted)
PKA:4.42±0.10(Predicted)
Density:1.41±0.1 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

There total 4 articles about (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 527758-07-2
tert-butyl (E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate

: 527758-08-3
(E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1021/jm0204035

Reference yield:

: 129686-16-4
6-bromo-3,4-dihydro-1,8-naphthyridine-2(1H)-one

: 527758-08-3
(E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / Pd(OAc)2; P(tolyl)3; DIEA / various solvent(s); dimethylformamide / 18 h / Heating

2: 100 percent / TFA / CH₂Cl₂ / 0.5 h

With palladium diacetate; P(tolyl)3; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1021/jm0204035

Reference yield:

: 335031-10-2
6-bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylic acid methyl ester

: 527758-08-3
(E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 4 h / Heating

2: aq. HCl / Heating

3: 45 percent / Pd(OAc)2; P(tolyl)3; DIEA / various solvent(s); dimethylformamide / 18 h / Heating

4: 100 percent / TFA / CH₂Cl₂ / 0.5 h

With hydrogenchloride; palladium diacetate; sodium hydroxide; P(tolyl)3; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 3: Heck coupling;
DOI:10.1021/jm0204035