C₁₆H₁₅ClN₄O₃

Base Information

• Chemical Name: C₁₆H₁₅ClN₄O₃
• CAS No.: 1611446-03-7
• Molecular Formula: C₁₆H₁₅ClN₄O₃
• Molecular Weight: 346.773
• Mol file: 1611446-03-7.mol

Synonyms:C₁₆H₁₅ClN₄O₃

Chemical Property of C₁₆H₁₅ClN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₅ClN₄O₃

There total 3 articles about C₁₆H₁₅ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

C14H20BClO3 (1310956-28-5) + C10H11BrN4O2 (882293-87-0) → C16H15ClN4O3 (1611446-03-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 17h;

Reference yield:

1-bromo-4-chloro-3-ethoxybenzene (900174-61-0) → C16H15ClN4O3 (1611446-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 5 h / 90 °C

2: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 17 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium acetate; sodium carbonate; In 1,4-dioxane;

Reference yield:

5-bromo-2-chlorophenol (183802-98-4) → C16H15ClN4O3 (1611446-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C

2: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 5 h / 90 °C

3: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 17 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium acetate; sodium carbonate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

5-bromo-2-chlorophenol

1-bromo-4-chloro-3-ethoxybenzene

C₁₄H₂₀BClO₃

C₁₀H₁₁BrN₄O₂

Refernces