(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

Base Information

Chemical Name:(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one
CAS No.:482351-07-5
Molecular Formula:C₃₁H₄₁NO₈Si
Molecular Weight:583.754
Hs Code.:

(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

Synonyms:(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

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Chemical Property of (5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

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Technology Process of (5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

There total 8 articles about (5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 482351-22-4
(5R,6R)-5-[(1E)-3-[(4-methoxyphenyl)methoxy]-1-[[[tris-(1-methylethyl)silyl]oxy]methyl]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

: 482351-07-5
(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; for 50h;
DOI:10.1021/ja028457r

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 482351-07-5
(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

With triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.06.141

Reference yield:

: 76074-18-5
trimethyl-(2-nitro-phenyl)-stannane

: 482351-07-5
(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide / 48 h / 20 °C

2: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

3: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenyl-arsane; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1016/j.tet.2004.06.141