3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

Base Information

Chemical Name:3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide
CAS No.:1346147-60-1
Molecular Formula:C₁₉H₁₇ClF₄N₄O₂
Molecular Weight:444.816
Hs Code.:

Synonyms:3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

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Chemical Property of 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

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Technology Process of 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

There total 16 articles about 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346146-82-4
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-ethoxy-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluorophenyl]amide

: 1346147-60-1
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

Guidance literature:: With ammonium chloride; In methanol; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 1262859-53-9
4-bromo-1-fluoro-2-isopropenyl-benzene

: 1346147-60-1
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

Guidance literature:: Multi-step reaction with 14 steps

1: iodine / ethyl acetate; acetonitrile / 16.75 h / 0 - 20 °C / Inert atmosphere; Darkness

2: silver tetrafluoroborate / N,N-dimethyl-formamide; tert-butyl alcohol / 16 h / 80 °C

3: Chiralpak AD / n-heptane; ethanol

4: lithium hydroxide monohydrate / ethanol; water / 100 °C

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.5 h / 20 °C

6: dmap; triethylamine / dichloromethane / 16 h / 20 °C

7: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

9: trifluoroacetic acid; trifluorormethanesulfonic acid / methoxybenzene / 24 h / 20 - 73 °C

10: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos / toluene / 16 h / 105 °C / Inert atmosphere; Sealed vial

11: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

12: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

13: dichloromethane / 16 h / 20 °C / Inert atmosphere

14: ammonium chloride / methanol / 16 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; dmap; silver tetrafluoroborate; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; chloroform; water; ethyl acetate; methoxybenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1266785-96-9
(R)-2-(5-bromo-2-fluoro-phenyl)-2-(4-methoxy-benzylamino)-propan-1-ol

: 1346147-60-1
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]amide

Guidance literature:: Multi-step reaction with 9 steps

1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

2: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

4: trifluoroacetic acid; trifluorormethanesulfonic acid / methoxybenzene / 24 h / 20 - 73 °C

5: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos / toluene / 16 h / 105 °C / Inert atmosphere; Sealed vial

6: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

8: dichloromethane / 16 h / 20 °C / Inert atmosphere

9: ammonium chloride / methanol / 16 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; dmap; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; methoxybenzene; N,N-dimethyl-formamide; toluene;