(4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid

Base Information

• Chemical Name: (4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid
• CAS No.: 155880-11-8
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.186
• Mol file: 155880-11-8.mol

Synonyms:(4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid

Chemical Property of (4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid

There total 3 articles about (4R)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-(2'-hydroxyphenyl)-4(R)-oxazolinecarboxylate → (4R)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-11-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00036a005

Reference yield:

2-hydroxybenzimino ethyl ether (20857-12-9) → (4R)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / Heating

2: H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00036a005

Reference yield:

N-[2-(benzyloxy)benzoyl]-D-serine benzyl ester → (4R)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hexaammonium heptamolybdate tetrahydrate / toluene / 110 °C / Dean-Stark; Inert atmosphere

2: 10% Pd/C; hydrogen / methanol / 1 h / 25 °C / 2280.15 Torr

With hexaammonium heptamolybdate tetrahydrate; 10% Pd/C; hydrogen; In methanol; toluene;

DOI:10.1021/np200972s

upstream raw materials:

2-hydroxybenzimino ethyl ether

Downstream raw materials:

C₆₄H₉₉N₅O₁₁Si₂

C₆₄H₉₉N₅O₁₁Si₂

C₄₇H₆₁N₅O₁₀

C₄₇H₆₁N₅O₁₀