Buspirone hydrochloride

Base Information

Chemical Name:Buspirone hydrochloride
CAS No.:33386-08-2
Molecular Formula:C₂₁H₃₁N₅O₂*ClH
Molecular Weight:421.97
Hs Code.:29335995
European Community (EC) Number:251-489-4
NSC Number:759571,751138
UNII:207LT9J9OC
DSSTox Substance ID:DTXSID1037193
Wikidata:Q27105997
NCI Thesaurus Code:C26641
RXCUI:203116
ChEMBL ID:CHEMBL1200399
Mol file:33386-08-2.mol

Synonyms:Anxut;Apo Buspirone;Apo-Buspirone;Bespar;Busp;Buspar;Buspirone;Buspirone Hydrochloride;Gen Buspirone;Gen-Buspirone;Hydrochloride, Buspirone;Lin Buspirone;Lin-Buspirone;MJ 9022 1;MJ-9022-1;MJ90221;N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide;Neurosine;Novo Buspirone;Novo-Buspirone;Nu Buspirone;Nu-Buspirone;PMS Buspirone;PMS-Buspirone;ratio Buspirone;ratio-Buspirone

Suppliers and Price of Buspirone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AHH
Buspirone hydrochloride 98%
25g
$ 255.00

AK Scientific
BuspironeHCl
5g
$ 264.00

Alfa Aesar
Buspirone hydrochloride
1g
$ 50.50

Alfa Aesar
Buspirone hydrochloride
5g
$ 188.00

American Custom Chemicals Corporation
BUSPIRONE HYDROCHLORIDE 95.00%
1G
$ 153.30

American Custom Chemicals Corporation
BUSPIRONE HYDROCHLORIDE 95.00%
2.5G
$ 836.00

Biosynth Carbosynth
Buspirone hydrochloride
25 g
$ 375.00

Biosynth Carbosynth
Buspirone hydrochloride
5 g
$ 125.00

Biosynth Carbosynth
Buspirone hydrochloride
10 g
$ 200.00

Biosynth Carbosynth
Buspirone hydrochloride
2 g
$ 70.00

Total 148 raw suppliers

Chemical Property of Buspirone hydrochloride

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:5.24E-15mmHg at 25°C
Melting Point:201.5-202.5 °C
Boiling Point:613.9 °C at 760 mmHg
Flash Point:325.1 °C
PSA：69.64000
Density:1.24g/cm3
LogP:2.83100
Storage Temp.:2-8°C
Solubility.:Freely soluble in water and in methanol, practically insoluble in acetone.
Water Solubility.:Soluble in methanol (50 mg/ml), water (partly), DMSO (100 mM).
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:421.2244530
Heavy Atom Count:29
Complexity:529

Purity/Quality:

99% ^*data from raw suppliers

Buspirone hydrochloride 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s): T, Xn
Hazard Codes:T,Xn,F
Statements: 25-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 45-36-26-36/37-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
Recent ClinicalTrials:Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury
Recent EU Clinical Trials:Open-Label Extension Study of JM-010 in Parkinson’s Disease Patients With Dyskinesia
Description Buspirone hydrochloride is an anxiolytic agent indicated for the management of anxiety disorders with or without accompanying depression. In contrast to the benzodiazepines, buspirone does not interact with alcohol, and lacks sedative, anticonvulsant, and muscle relaxant effects, and abuse potential.
Uses Non-benzodiazepine anxiolitic; 5-hydroxytryptamine (5-HT1) receptor agonist. anxiolitic;serotonin receptor agonist
Therapeutic Function Anxiolytic
Clinical Use Anxiolytic
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: concentration increased by erythromycin - reduce dose; concentration reduced by rifampicin. Antidepressants: avoid with tranylcypromine; risk of severe hypertension with MAOIs - avoid. Antifungals: concentration increased by itraconazole - reduce dose. Antipsychotics: enhanced sedative effects; haloperidol concentration increased. Antivirals: concentration increased by ritonavir, increased risk of toxicity. Calcium-channel blockers: concentration increased by diltiazem and verapamil - reduce dose. Grapefruit juice: concentration increased by grapefruit juice - reduce dose. Methylthioninium: possible risk of CNS toxicity - avoid if possible.

Technology Process of Buspirone hydrochloride

There total 7 articles about Buspirone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

: 110-52-1
1,4-dibromo-butane

: 20980-22-7
N-(2-pyridinyl)piperazine

: 1075-89-4
tetramethylene glutarimide

: 33386-08-2,116753-41-4
buspirone hydrochloride

Guidance literature:: tetramethylene glutarimide; With potassium hydroxide; In ethanol; at 20 ℃; for 2h;

1,4-dibromo-butane; In acetone; at 50 ℃; for 8h;

N-(2-pyridinyl)piperazine; With potassium carbonate; In acetone; butan-1-ol; for 15h; Reflux;
DOI:10.1007/s11164-011-0311-1

Reference yield:

: 33386-08-2,116753-41-4
buspirone hydrochloride

: 36505-84-7
BUSPIRONE

Guidance literature:

Reference yield:

: C₁₃H₂₃NO

: 94021-22-4
1-(2-pyrimidyl)piperazine dihydrochloride

: 33386-08-2,116753-41-4
buspirone hydrochloride

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1002/ardp.201100112