[2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester

Base Information

• Chemical Name: [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester
• CAS No.: 135949-57-4
• Molecular Formula: C₂₈H₃₂N₂O₃S₂
• Molecular Weight: 508.706
• Mol file: 135949-57-4.mol

Synonyms:[2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester

Chemical Property of [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester

There total 7 articles about [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester (135949-89-2) → [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester (135949-57-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm00091a016

Reference yield:

(S)-tert-butyl (1-mercapto-3-phenylpropan-2-yl)carbamate (141437-85-6,1217604-63-1) → [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester (135949-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / CH₃COOH / ethanol / Ambient temperature

2: 61 percent / ethanol / Ambient temperature

3: 85 percent / CF₃COOH / CH₂Cl₂ / 3 h / 0 - 20 °C

With acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1021/jm00091a016

Reference yield:

(S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate (122818-32-0) → [2-((S)-2-Amino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester (135949-57-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / 1 M NaOH / ethanol / 3 h / 0 - 20 °C

2: 51 percent / CH₃COOH / ethanol / Ambient temperature

3: 61 percent / ethanol / Ambient temperature

4: 85 percent / CF₃COOH / CH₂Cl₂ / 3 h / 0 - 20 °C

With sodium hydroxide; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1021/jm00091a016

upstream raw materials:

[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionylamino]-acetic acid benzyl ester

(S)-tert-butyl (1-mercapto-3-phenylpropan-2-yl)carbamate

(S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate

[(S)-2-Phenyl-1-(pyridin-2-yldisulfanylmethyl)-ethyl]-carbamic acid tert-butyl ester