9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

Base Information

• Chemical Name: 9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione
• CAS No.: 1196060-21-5
• Molecular Formula: C₁₉H₁₆BrCl₂N₃O₂
• Molecular Weight: 469.165
• Mol file: 1196060-21-5.mol

Synonyms:9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

Chemical Property of 9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

There total 1 articles about 9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

7-benzyl-9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione (1196060-20-4) → 9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione (1196060-21-5)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; at 5 - 80 ℃; for 19.5h; Inert atmosphere;

DOI:10.1002/jlcr.1596

Reference yield:

9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione (1196060-21-5) + (1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → C10H16O4S*C19H16BrCl2N3O2

Guidance literature:

In dichloromethane; tert-butyl methyl ether; at 20 ℃; for 2h; Resolution of racemate;

DOI:10.1002/jlcr.1596

Reference yield:

9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione (1196060-21-5) + (1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → C10H16O4S*C19H16BrCl2N3O2 (1196060-31-7)

Guidance literature:

In dichloromethane; for 0.666667h; Resolution of racemate;

DOI:10.1002/jlcr.1596

upstream raw materials:

7-benzyl-9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

Downstream raw materials:

9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

9-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1-methyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione

C₁₀H₁₆O₄S*C₁₉H₁₆BrCl₂N₃O₂