6-Hydroxydopamine hydrobromide

Base Information

• Chemical Name: 6-Hydroxydopamine hydrobromide
• CAS No.: 636-00-0
• Molecular Formula: C8H11 N O3 . Br H
• Molecular Weight: 250.092
• Hs Code.: 2922299090
• European Community (EC) Number: 211-247-0
• NSC Number: 238469
• UNII: TWC1D4W0WB
• DSSTox Substance ID: DTXSID30212972
• Wikidata: Q27290460
• ChEMBL ID: CHEMBL1718398
• Mol file: 636-00-0.mol

Synonyms:6 Hydroxydopamine;6-Hydroxydopamine;6-OHDA;Hydrobromide, Oxidopamine;Hydrochloride, Oxidopamine;Oxidopamine;Oxidopamine Hydrobromide;Oxidopamine Hydrochloride

Chemical Property of 6-Hydroxydopamine hydrobromide

Chemical Property:

• Appearance/Colour: beige to brown fine crystalline powder
• Vapor Pressure: 3.58E-07mmHg at 25°C
• Melting Point: 216-220 °C(lit.)
• Boiling Point: 406oC at 760 mmHg
• Flash Point: 199.3oC
• PSA: 86.71000
• LogP: 1.96300
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 249.00006
• Heavy Atom Count: 13
• Complexity: 142

Purity/Quality:

98% ^*data from raw suppliers

6-Hydroxydopamine hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1O)O)O)CCN.Br
• Description: 6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.
• Uses: 6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.