4-fluoro-19-nortestosterone

Base Information

• Chemical Name: 4-fluoro-19-nortestosterone
• CAS No.: 1881-31-8
• Molecular Formula: C₁₈H₂₅FO₂
• Molecular Weight: 292.394
• Mol file: 1881-31-8.mol

Synonyms:Estr-4-en-3-one,4-fluoro-17b-hydroxy- (6CI,7CI,8CI);4-Fluoro-17b-hydroxyest-4-ene-3-one;4-Fluoro-19-nortestosterone; RU 1166

Chemical Property of 4-fluoro-19-nortestosterone

Chemical Property:

• Vapor Pressure: 4.1E-09mmHg at 25°C
• Boiling Point: 427.8°Cat760mmHg
• Flash Point: 212.5°C
• PSA: 37.30000
• Density: 1.18g/cm³
• LogP: 3.78630

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluoro-19-nortestosterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-19-nortestosterone is used in biological studies as a ketosteroid fluoro derivative which acts as a testosterone reductase inhibitor and as neoplasm inhibitors in prostate cancer.

Technology Process of 4-fluoro-19-nortestosterone

There total 5 articles about 4-fluoro-19-nortestosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

19-nortestosterone enamine (10582-50-0) → 4-fluoro-19-nortestosterone (1881-31-8)

Guidance literature:

With hydrogenchloride; perchloryl fluoride; Yield given. Multistep reaction; 1.) aqueous methanol, -20 deg C, 2.5 h, 2.) DMF, 24 h, room temperature;

DOI:10.1021/jo00155a015

Reference yield:

4-Fluor-17β-hydroxy-3-oxo-19-nor-androsten-(5) → 4-fluoro-19-nortestosterone (1881-31-8)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide;

Reference yield:

→ 4-Fluor-3-oxo-19-nor-androsten-(4)-ol-(17β) (1881-31-8)

Guidance literature:

Hemiacetal 2, HCl;

upstream raw materials:

19-nortestosterone enamine

Downstream raw materials:

4-Fluoroestradiol