2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

Base Information

Chemical Name:2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one
CAS No.:1338825-87-8
Molecular Formula:C₂₀H₁₇F₃O₄
Molecular Weight:378.348
Hs Code.:

Synonyms:2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

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Chemical Property of 2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

Chemical Property:

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Technology Process of 2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

There total 8 articles about 2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 2-ethyl-7-hydroxy-8-(hydroxymethyl)-4H-chromen-4-one

: 402-23-3
1-bromomethyl-3-trifluoromethylbenzene

: 1338825-87-8
2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;
DOI:10.1016/j.ejmech.2011.07.051

Reference yield:

: 942133-85-9
1-[2-hydroxy-4-(methoxymethoxy)-3-methylphenyl]ethanone

: 1338825-87-8
2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / Inert atmosphere; Reflux

1.2: pH 8 / Inert atmosphere

2.1: hydrogenchloride; water / ethanol / 0.75 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

5.1: acetic anhydride / 2 h / Reflux

6.1: hydrogenchloride; water / ethanol / 2 h / Reflux

7.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; water; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2011.07.051

Reference yield:

: 1268165-63-4
2-ethyl-7-(methoxymethoxy)-8-methyl-4H-chromen-4-one

: 1338825-87-8
2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

2: acetic anhydride / 2 h / Reflux

3: hydrogenchloride; water / ethanol / 2 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; water; acetic anhydride; potassium carbonate; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.07.051